Leucotropin™ (GM-CSF)

Cangene’s Leucotropin™ is a recombinant human Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) obtained from the bacterial fermentation of Streptomyces lividans transformed with a genetically engineered plasmid containing the rhGM-CSF gene. The amino acid sequence of Leucotropin™ is identical to the natural molecule but it is non-glycosylated.

Leucotropin™ is a highly purified preparation of a monomeric, biologically active molecule with a theoretical molecular weight of 14,478 Daltons based on the amino acid sequence of the natural molecule. The preparation is sterile and water soluble.

The biological activity of the product has been demonstrated in cell proliferation assays (AML-193 and TF-1 cell lines) and also with a colony stimulating assay employing human bone marrow cells.